Transforming growth factor-β receptor 2 gene polymorphisms are associated with end-stage renal disease.

ABSTRACT: BACKGROUND:Transforming growth factor-beta (TGF-β) is a multifunctional cytokine involved in immune disorders, cancer, asthma, lung fibrosis, and chronic kidney disease, and its signal pathways are considered crucial mediators of a variety of cellular processes. In addition, several recent studies have reported that TGF-β receptor (TGF-βR) gene polymorphism is associated with chronic kidney disease. However, the association between end-stage renal disease (ESRD) and the TGF-β gene polymorphism has not been sufficiently investigated. In this study, we hypothesized that polymorphisms of the TGF-β ligands or their receptors may be related to ESRD. METHODS:We assessed the relationship between four single-nucleotide polymorphisms (SNPs) in the TGF-βR2 and TGF-β2 genes and ESRD, in 312 patients

SUBMITTER: Ki HJ 

PROVIDER: S-EPMC4570595 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature