Avian pathogenic Escherichia coli (APEC) infection alters bone marrow transcriptome in chickens.

ABSTRACT:

Background

Avian pathogenic Escherichia coli (APEC) is a major cause of disease impacting animal health. The bone marrow is the reservoir of immature immune cells; however, it has not been examined to date for gene expression related to developmental changes (cell differentiation, maturation, programming) after APEC infection. Here, we study gene expression in the bone marrow between infected and non-infected animals, and between infected animals with mild (resistant) versus severe (susceptible) pathology, at two times post-infection.

Results

We sequenced 24 bone marrow RNA libraries generated from the six different treatment groups with four replicates each, and obtained an average of 22 million single-end, 100-bp reads per library. Genes were detected as differentially exp

SUBMITTER: Sun H 

PROVIDER: S-EPMC4570614 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature