Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals.

ABSTRACT:

Objectives

Surveillance drug resistance mutations (SDRMs) in drug-naive patients are typically used to survey HIV-1-transmitted drug resistance (TDR). We test here how SDRMs in patients failing treatment, the original source of TDR, contribute to assessing TDR, transmissibility and transmission source of SDRMs.

Design

This is a retrospective observational study analyzing a Portuguese cohort of HIV-1-infected patients.

Methods

The prevalence of SDRMs to protease inhibitors, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) in drug-naive and treatment-failing patients was measured for 3554 HIV-1 subtype B patients. Transmission ratio (prevalence in drug-naive/prevalence in treatment-failing patients), average

SUBMITTER: Winand R 

PROVIDER: S-EPMC4570689 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature