Copy number alterations detected by whole-exome and whole-genome sequencing of esophageal adenocarcinoma.

ABSTRACT:

Background

Esophageal adenocarcinoma (EA) is among the leading causes of cancer mortality, especially in developed countries. A high level of somatic copy number alterations (CNAs) accumulates over the decades in the progression from Barrett's esophagus, the precursor lesion, to EA. Accurate identification of somatic CNAs is essential to understand cancer development. Many studies have been conducted for the detection of CNA in EA using microarrays. Next-generation sequencing (NGS) technologies are believed to have advantages in sensitivity and accuracy to detect CNA, yet no NGS-based CNA detection in EA has been reported.

Results

In this study, we analyzed whole-exome (WES) and whole-genome sequencing (WGS) data for detecting CNA from a published large-scale genomic study o

SUBMITTER: Wang X 

PROVIDER: S-EPMC4570720 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature