A close look at protein function prediction evaluation protocols.

ABSTRACT:

Background

The recently held Critical Assessment of Function Annotation challenge (CAFA2) required its participants to submit predictions for a large number of target proteins regardless of whether they have previous annotations or not. This is in contrast to the original CAFA challenge in which participants were asked to submit predictions for proteins with no existing annotations. The CAFA2 task is more realistic, in that it more closely mimics the accumulation of annotations over time. In this study we compare these tasks in terms of their difficulty, and determine whether cross-validation provides a good estimate of performance.

Results

The CAFA2 task is a combination of two subtasks: making predictions on annotated proteins and making predictions on previously unannotat

SUBMITTER: Kahanda I 

PROVIDER: S-EPMC4570743 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature