Anxiety-like behavior in Rett syndrome: characteristics and assessment by anxiety scales.

ABSTRACT:

Background

Rett syndrome (RTT) is a severe neurodevelopmental disorder characterized by regression of language and motor skills, cognitive impairment, and frequent seizures. Although the diagnostic criteria focus on communication, motor impairments, and hand stereotypies, behavioral abnormalities are a prevalent and disabling component of the RTT phenotype. Among these problematic behaviors, anxiety is a prominent symptom. While the introduction of the Rett Syndrome Behavioral Questionnaire (RSBQ) represented a major advancement in the field, no systematic characterization of anxious behavior using the RSBQ or other standardized measures has been reported.

Methods

This study examined the profiles of anxious behavior in a sample of 74 girls with RTT, with a focus on identifyi

SUBMITTER: Barnes KV 

PROVIDER: S-EPMC4571061 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature