JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats.

ABSTRACT: Neuropathic pain, a debilitating pain condition, is a common consequence of damage to the nervous system. Optimal treatment of neuropathic pain is a major clinical challenge because the underlying mechanisms remain unclear and currently available treatments are frequently ineffective. Emerging lines of evidence indicate that peripheral nerve injury converts resting spinal cord glia into reactive cells that are required for the development and maintenance of neuropathic pain. However, the mechanisms underlying reactive astrogliosis after nerve injury are largely unknown. In the present study, we investigated cell proliferation, a critical process in reactive astrogliosis, and determined the temporally restricted proliferation of dorsal horn astrocytes in rats with spinal nerve injury, a wel

SUBMITTER: Tsuda M 

PROVIDER: S-EPMC4571138 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature