A prospective, randomized clinical trial of antiretroviral therapies on carotid wall thickness.

ABSTRACT:

Objective

This article compares the effects of initiating three contemporary antiretroviral therapy (ART) regimens on progression of carotid artery intima-media thickness (IMT) over 3 years.

Design

Randomized clinical trial.

Setting

Multicenter (26 institutions).

Patients

ART-naive HIV-infected individuals (n = 328) without known cardiovascular disease or diabetes mellitus.

Intervention

Random assignment to tenofovir/emtricitabine along with atazanavir/ritonavir (ATV/r), darunavir/ritonavir (DRV/r), or raltegravir (RAL).

Main outcome measures

Right-sided carotid IMT was evaluated by B-mode ultrasonography before ART initiation, and then after 48, 96, and 144 weeks. Comparisons of yearly rates of change in carotid IMT used mixed-effects linear regr

SUBMITTER: Stein JH 

PROVIDER: S-EPMC4571277 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature