A genetic model of the effects of insecticide-treated bed nets on the evolution of insecticide-resistance.

ABSTRACT:

Background and objectives

The evolution of insecticide-resistance in malaria vectors is emerging as a serious challenge for the control of malaria. Modelling the spread of insecticide-resistance is an essential tool to understand the evolutionary pressures and dynamics caused by the application of insecticides.

Methodology

We developed a population-genetic model of the spread of insecticide-resistance in a population of Anopheles vectors in response to insecticides used either as adulticides (focussing on insecticide-treated bed nets (ITNs)) or as larvicides (either for the control of malaria or, as an inadvertent side-product, in agriculture).

Results

We show that indoor use of insecticides leads to considerably less selection pressure than their use as larvicides, s

SUBMITTER: Birget PL 

PROVIDER: S-EPMC4571732 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature