Proton pump inhibitors and the risk of acute kidney injury in older patients: a population-based cohort study.

ABSTRACT:

Background

Proton pump inhibitors (PPIs) cause interstitial nephritis and are an underappreciated cause of acute kidney injury. We examined the risk of acute kidney injury and acute interstitial nephritis in a large population of older patients receiving PPIs.

Methods

We conducted a population-based study involving Ontario residents aged 66 years and older who initiated PPI therapy between Apr. 1, 2002, and Nov. 30, 2011. We used propensity score matching to establish a highly comparable reference group of control patients. The primary outcome was hospital admission with acute kidney injury within 120 days, and a secondary analysis examined acute interstitial nephritis. We used Cox proportional hazards regression to adjust for differences between groups.

Results

We st

SUBMITTER: Antoniou T 

PROVIDER: S-EPMC4571830 | biostudies-literature | 2015 Apr-Jun

REPOSITORIES: biostudies-literature