The risk of pancreatitis with sitagliptin therapy in older adults: a population-based cohort study.

ABSTRACT:

Background

The risk of pancreatitis with sitagliptin use in routine care remains to be established in older patients. We aimed to determine this risk in older adults who were newly prescribed sitagliptin versus an alternative hypoglycemic agent in the outpatient setting.

Methods

In a population-based retrospective cohort study in Ontario from 2010 until 2012 involving adults aged 66 years and older, we studied those who were newly prescribed sitagliptin or an alternative hypoglycemic agent. Our primary outcome of interest was a hospital encounter (emergency department visit or hospital admission) with acute pancreatitis within 90 days. We used inverse probability of treatment weighting to balance the 2 groups and logistic regression with a robust variance estimate to calcula

SUBMITTER: Clemens KK 

PROVIDER: S-EPMC4571832 | biostudies-literature | 2015 Apr-Jun

REPOSITORIES: biostudies-literature