Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo.

ABSTRACT:

Background

Potent chemotherapy for advanced gastric cancer has not been completely established. Many molecularly targeted therapies are under investigation, but their therapeutic outcomes are not promising because they do not target specific and/or critical targets of gastric carcinogenesis. Although the molecular basis of gastric carcinogenesis remains poorly understood, nuclear localization of β-catenin was observed in approximately 50 % of gastric cancer specimens. Recent studies have suggested that activation of signal transducer and activator of transcription 3 (STAT3) contributes to gastric carcinogenesis in a mouse model. A newly synthesized curcumin analog has inhibitory potential against β-catenin and STAT3.

Methods

Using a transgenic mouse model of gastric cancer i

SUBMITTER: Uehara Y 

PROVIDER: S-EPMC4572076 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature