Association between Obesity and Cervical Microflora Dominated by Lactobacillus iners in Korean Women.

ABSTRACT: Lactobacillus spp. are associated with the maintenance of reproductive health, but obesity reduces fertility and is a risk factor for obstetric and neonatal complications. We assessed the association between obesity and the cervical Lactobacillus composition, which has not been examined previously. Pyrosequencing was performed using cervical swabs collected from 76 normal participants with negative results for cervical intraepithelial neoplasia (CIN) and 57 participants with CIN, based on histological examinations. Cluster analysis of nine Lactobacillus spp. was performed, and five cluster types were identified. The association between obesity and the Lactobacillus community was assessed by logistic regression analysis after adjustment for confounding factors. The proportion of Lactobacill

SUBMITTER: Oh HY 

PROVIDER: S-EPMC4572524 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature