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Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Traced to Clonal Expansion of an mgrB Deletion Mutant.

ABSTRACT: We describe a large hospital outbreak (93 bloodstream infections) of colistin-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates which was mirrored by increased colistin consumption. The outbreak was mostly traced to the clonal expansion of an mgrB deletion mutant of an ST512 strain that produced KPC-3.

SUBMITTER: Giani T 

PROVIDER: S-EPMC4572530 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Traced to Clonal Expansion of an mgrB Deletion Mutant.

Giani Tommaso T   Arena Fabio F   Vaggelli Guendalina G   Conte Viola V   Chiarelli Adriana A   Henrici De Angelis Lucia L   Fornaini Rossella R   Grazzini Maddalena M   Niccolini Fabrizio F   Pecile Patrizia P   Rossolini Gian Maria GM  

Journal of clinical microbiology 20150722 10

We describe a large hospital outbreak (93 bloodstream infections) of colistin-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates which was mirrored by increased colistin consumption. The outbreak was mostly traced to the clonal expansion of an mgrB deletion mutant of an ST512 strain that produced KPC-3. ...[more]

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