Hormetic effect of rotenone in primary human fibroblasts.

ABSTRACT:

Background

Rotenone inhibits the electron transfer from complex I to ubiquinone, in this way interfering with the electron transport chain in mitochondria. This chain of events induces increased levels of intracellular reactive oxygen species, which in turn can contribute to acceleration of telomere shortening and induction of DNA damage, ultimately resulting in aging. In this study, we investigated the effect of rotenone treatment in human fibroblast strains.

Results

For the first time we here describe that rotenone treatment induced a hormetic effect in human fibroblast strains. We identified a number of genes which were commonly differentially regulated due to low dose rotenone treatment in fibroblasts independent of their cell origin. However, these genes were not among

SUBMITTER: Marthandan S 

PROVIDER: S-EPMC4572608 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature