Age-driven modulation of tRNA-derived fragments in Drosophila and their potential targets.

ABSTRACT:

Background

Development of sequencing technologies and supporting computation enable discovery of small RNA molecules that previously escaped detection or were ignored due to low count numbers. While the focus in the analysis of small RNA libraries has been primarily on microRNAs (miRNAs), recent studies have reported findings of fragments of transfer RNAs (tRFs) across a range of organisms.

Results

Here we describe Drosophila melanogaster tRFs, which appear to have a number of structural and functional features similar to those of miRNAs but are less abundant. As is the case with miRNAs, (i) tRFs seem to have distinct isoforms preferentially originating from 5' or 3' end of a precursor molecule (in this case, tRNA), (ii) ends of tRFs appear to contain short "seed" sequences

SUBMITTER: Karaiskos S 

PROVIDER: S-EPMC4572633 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature