Polymorphism profiling of nine high altitude relevant candidate gene loci in acclimatized sojourners and adapted natives.

ABSTRACT:

Background

Sea level sojourners, on ascent to high altitude, undergo acclimatization through integrated physiological processes for defending the body against oxygen deprivation while the high altitude natives (resident population) are adapted to the prevailing hypobaric hypoxic condition through natural selection. Separating the acclimatization processes from adaptive changes and identifying genetic markers in lowlanders that may be beneficial for offsetting the high altitude hypoxic stress, although challenging, is worth investigating. We genotyped nine candidate gene polymorphisms, suggested to be relevant in high altitude environment, in sea level acclimatized sojourners and adapted natives for understanding differences/commonality between the acclimatized and the adapted cohor

SUBMITTER: Tomar A 

PROVIDER: S-EPMC4572652 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature