Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study.

ABSTRACT:

Introduction

Consensus criteria for pediatric severe sepsis have standardized enrollment for research studies. However, the extent to which critically ill children identified by consensus criteria reflect physician diagnosis of severe sepsis, which underlies external validity for pediatric sepsis research, is not known. We sought to determine the agreement between physician diagnosis and consensus criteria to identify pediatric patients with severe sepsis across a network of international pediatric intensive care units (PICUs).

Methods

We conducted a point prevalence study involving 128 PICUs in 26 countries across 6 continents. Over the course of 5 study days, 6925 PICU patients <18 years of age were screened, and 706 with severe sepsis defined either by physician diagnosis

SUBMITTER: Weiss SL 

PROVIDER: S-EPMC4572676 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature