Default mode network segregation and social deficits in autism spectrum disorder: Evidence from non-medicated children.

ABSTRACT: Functional pathology of the default mode network is posited to be central to social-cognitive impairment in autism spectrum disorders (ASD). Altered functional connectivity of the default mode network's midline core may be a potential endophenotype for social deficits in ASD. Generalizability from prior studies is limited by inclusion of medicated participants and by methods favoring restricted examination of network function. This study measured resting-state functional connectivity in 22 8-13 year-old non-medicated children with ASD and 22 typically developing controls using seed-based and network segregation functional connectivity methods. Relative to controls the ASD group showed both under- and over-functional connectivity within default mode and non-default mode regions, respectivel

SUBMITTER: Yerys BE 

PROVIDER: S-EPMC4573091 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature