PKCε Is an Essential Mediator of Prostate Cancer Bone Metastasis.

ABSTRACT:

Unlabelled

The bone is a preferred site for metastatic homing of prostate cancer cells. Once prostate cancer patients develop skeletal metastases, they eventually succumb to the disease; therefore, it is imperative to identify key molecular drivers of this process. This study examines the involvement of protein kinase C epsilon (PKCε), an oncogenic protein that is abnormally overexpressed in human tumor specimens and cell lines, on prostate cancer cell bone metastasis. PC3-ML cells, a highly invasive prostate cancer PC3 derivative with bone metastatic colonization properties, failed to induce skeletal metastatic foci upon inoculation into nude mice when PKCε expression was silenced using shRNA. Interestingly, while PKCε depletion had only marginal effects on the proliferative, adhe

SUBMITTER: Gutierrez-Uzquiza A 

PROVIDER: S-EPMC4573355 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature