Dataset Information
Pathway analysis supports association of nonsyndromic cryptorchidism with genetic loci linked to cytoskeleton-dependent functions.
Ontology highlight
ABSTRACT:
SUBMITTER: Barthold JS
PROVIDER: S-EPMC4573451 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Pathway analysis supports association of nonsyndromic cryptorchidism with genetic loci linked to cytoskeleton-dependent functions.
Human reproduction (Oxford, England) 20150724 10
<h4>Study question</h4>What are the genetic loci that increase susceptibility to nonsyndromic cryptorchidism, or undescended testis?<h4>Summary answer</h4>A genome-wide association study (GWAS) suggests that susceptibility to cryptorchidism is heterogeneous, with a subset of suggestive signals linked to cytoskeleton-dependent functions and syndromic forms of the disease.<h4>What is known already</h4>Population studies suggest moderate genetic risk of cryptorchidism and possible maternal and envi ...[more]