Understanding autoimmunity in the eye: from animal models to novel therapies.

ABSTRACT: In recent years considerable headway has been made on understanding the mechanisms underlying inflammatory diseases of the eye. This includes the role of the innate vs. adaptive arms of the immune systems in disease, the concept that distinct immune pathways can drive end-organ pathology, and the role as well as limitations of immune privilege in controlling the innate and adaptive effector responses that lead to eye pathology and loss of vision. These insights have largely been derived from basic studies in established and in newly developed animal models of uveitis. The increased understanding of disease mechanisms has the potential to guide development of rational therapies for human uveitis. Many novel biologics currently in use or being evaluated have been developed, or validated, in

SUBMITTER: Caspi RR 

PROVIDER: S-EPMC4573559 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature