Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer.

ABSTRACT: Although genome-wide association studies (GWAS) have separately identified many genetic susceptibility loci for ulcerative colitis (UC), Crohn's disease (CD) and colorectal cancer (CRC), there has been no large-scale examination for pleiotropy, or shared genetic susceptibility, for these conditions. We used logistic regression modeling to examine the associations of 181 UC and CD susceptibility variants previously identified by GWAS with risk of CRC using data from the Genetics and Epidemiology of Colorectal Cancer Consortium and the Colon Cancer Family Registry. We also examined associations of significant variants with clinical and molecular characteristics in a subset of the studies. Among 11794 CRC cases and 14190 controls, rs11676348, the susceptibility single nucleotide polymorphism

SUBMITTER: Khalili H 

PROVIDER: S-EPMC4573660 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature