Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development.

ABSTRACT: Aurora kinase B, one of the three members of the mammalian Aurora kinase family, is the catalytic component of the chromosomal passenger complex, an essential regulator of chromosome segregation in mitosis. Aurora B is overexpressed in human tumors although whether this kinase may function as an oncogene in vivo is not established. Here, we report a new mouse model in which expression of the endogenous Aurkb locus can be induced in vitro and in vivo. Overexpression of Aurora B in cultured cells induces defective chromosome segregation and aneuploidy. Long-term overexpression of Aurora B in vivo results in aneuploidy and the development of multiple spontaneous tumors in adult mice, including a high incidence of lymphomas. Overexpression of Aurora B also results in a reduced DNA damage respo

SUBMITTER: Gonzalez-Loyola A 

PROVIDER: S-EPMC4573715 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature