Ontology highlight
ABSTRACT:
SUBMITTER: Shanle EK
PROVIDER: S-EPMC4573853 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Genes & development 20150901 17
The YEATS domain, found in a number of chromatin-associated proteins, has recently been shown to have the capacity to bind histone lysine acetylation. Here, we show that the YEATS domain of Taf14, a member of key transcriptional and chromatin-modifying complexes in yeast, is a selective reader of histone H3 Lys9 acetylation (H3K9ac). Structural analysis reveals that acetylated Lys9 is sandwiched in an aromatic cage formed by F62 and W81. Disruption of this binding in cells impairs gene transcrip ...[more]