Ontology highlight
ABSTRACT:
SUBMITTER: Churchman ML
PROVIDER: S-EPMC4573904 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Cancer cell 20150827 3
Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of high-risk acute lymphoblastic leukemia (ALL), however the role of IKZF1 alterations in ALL pathogenesis is poorly understood. Here, we show that in mouse models of BCR-ABL1 leukemia, Ikzf1 and Arf alterations synergistically promote the development of an aggressive lymphoid leukemia. Ikzf1 alterations result in acquisition of stem cell-like features, including self-renewal and increased bone marrow stromal ...[more]