Ligand-Enabled Meta-C-H Alkylation and Arylation Using a Modified Norbornene.

ABSTRACT: 2-Carbomethoxynorbornene is identified as a more effective transient mediator to promote a Pd(II)-catalyzed meta-C(sp(2))-H alkylation of amides with various alkyl iodides as well as arylation with previously incompatible aryl iodides. The use of a tailor-made quinoline ligand is also crucial for this reaction to proceed.

SUBMITTER: Shen PX 

PROVIDER: S-EPMC4573956 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature