Methylome profiling reveals functions and genes which are differentially methylated in serrated compared to conventional colorectal carcinoma.

ABSTRACT:

Background

Serrated adenocarcinoma (SAC) is a recently recognized colorectal cancer (CRC) subtype accounting for 7.5-8.7 % of CRCs. It has been shown that SAC has a worse prognosis and different histological and molecular features compared to conventional carcinoma (CC) but, to date, there is no study analysing its methylome profile.

Results

The methylation status of 450,000 CpG sites using the Infinium Human Methylation 450 BeadChip array was investigated in 103 colorectal specimens, including 39 SACs and 34 matched CCs, from Spanish and Finnish patients. Microarray data showed a higher representation of morphogenesis-, neurogenesis-, cytoskeleton- and vesicle transport-related functions and also significant differential methylation of 15 genes, including the iodothyronine

SUBMITTER: Conesa-Zamora P 

PROVIDER: S-EPMC4574063 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature