Diet-induced variability of the resistin gene (Retn) transcript level and methylation profile in rats.

ABSTRACT:

Background

Adipose tissue is recognized as a highly active metabolic and endocrine organ. The hormones secreted by this tissue play an important role in many biochemical processes. It is known that dysfunction of adipocytes can cause insulin resistance, type 2 diabetes or hyperlipidemia. One of the important factors produced in fat tissue is resistin (Retn). It has been postulated that this hormone is involved in glucose homeostasis and insulin resistance. In the present study, the impact of five diet types (ad libitum normal, restricted, high-carbohydrate, high-fat and high-protein) on the Retn gene transcription and methylation profile was evaluated in rats of different ages.

Results

Transcript levels and methylation status of the Retn gene were studied in three tissues (m

SUBMITTER: Nowacka-Woszuk J 

PROVIDER: S-EPMC4574077 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature