Altered intestinal functions and increased local inflammation in insulin-resistant obese subjects: a gene-expression profile analysis.

ABSTRACT:

Background

Metabolic alterations relevant to postprandial dyslipidemia were previously identified in the intestine of obese insulin-resistant subjects. The aim of the study was to identify the genes deregulated by systemic insulin resistance in the intestine of severely obese subjects.

Methods

Transcripts from duodenal samples of insulin-sensitive (HOMA-IR < 3, n = 9) and insulin-resistant (HOMA-IR > 7, n = 9) obese subjects were assayed by microarray (Illumina HumanHT-12).

Results

A total of 195 annotated genes were identified as differentially expressed between these two groups (Fold change > 1.2). Of these genes, 36 were found to be directly involved in known intestinal functions, including digestion, extracellular matrix, endocrine system, immunity and cholesterol

SUBMITTER: Veilleux A 

PROVIDER: S-EPMC4574092 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature