Proteins from formalin-fixed paraffin-embedded prostate cancer sections that predict the risk of metastatic disease.

ABSTRACT:

Background

Prostate cancer is the most frequently diagnosed cancer in men and the third leading cause of cancer related deaths among men living in developed countries. Biomarkers that predict disease outcome at the time of initial diagnosis would substantially aid disease management.

Results

Proteins extracted from formalin-fixed paraffin-embedded tissue were identified using nanoflow liquid chromatography-MALDI MS/MS or after separation by one- or two-dimensional electrophoresis. The proteomics data have been deposited to the ProteomeXchange with identifier PXD000963. A list of potential biomarker candidates, based on proposed associations with prostate cancer, was derived from the 320 identified proteins. Candidate biomarkers were then examined by multiplexed Western blott

SUBMITTER: Dunne JC 

PROVIDER: S-EPMC4574128 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature