Quantitative Genetics of Food Intake in Drosophila melanogaster.

ABSTRACT: Food intake is an essential animal activity, regulated by neural circuits that motivate food localization, evaluate nutritional content and acceptance or rejection responses through the gustatory system, and regulate neuroendocrine feedback loops that maintain energy homeostasis. Excess food consumption in people is associated with obesity and metabolic and cardiovascular disorders. However, little is known about the genetic basis of natural variation in food consumption. To gain insights in evolutionarily conserved genetic principles that regulate food intake, we took advantage of a model system, Drosophila melanogaster, in which food intake, environmental conditions and genetic background can be controlled precisely. We quantified variation in food intake among 182 inbred, sequenced line

SUBMITTER: Garlapow ME 

PROVIDER: S-EPMC4574202 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature