Alginate-Iron Speciation and Its Effect on In Vitro Cellular Iron Metabolism.

ABSTRACT: Alginates are a class of biopolymers with known iron binding properties which are routinely used in the fabrication of iron-oxide nanoparticles. In addition, alginates have been implicated in influencing human iron absorption. However, the synthesis of iron oxide nanoparticles employs non-physiological pH conditions and whether nanoparticle formation in vivo is responsible for influencing cellular iron metabolism is unclear. Thus the aims of this study were to determine how alginate and iron interact at gastric-comparable pH conditions and how this influences iron metabolism. Employing a range of spectroscopic techniques under physiological conditions alginate-iron complexation was confirmed and, in conjunction with aberration corrected scanning transmission electron microscopy, nanopartic

SUBMITTER: Horniblow RD 

PROVIDER: S-EPMC4574481 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature