Novel miRNA-31 and miRNA-200a-Mediated Regulation of Retinoblastoma Proliferation.

ABSTRACT: Retinoblastoma is the most common intraocular tumor in children. Current management includes broad-based treatments such as chemotherapy, enucleation, laser therapy, or cryotherapy. However, therapies that target specific pathways important for retinoblastoma progression could provide valuable alternatives for treatment. MicroRNAs are short, noncoding RNA transcripts that can regulate the expression of target genes, and their aberrant expression often facilitates disease. The identification of post-transcriptional events that occur after the initiating genetic lesions could further define the rapidly aggressive growth displayed by retinoblastoma tumors. In this study, we used two phenotypically different retinoblastoma cell lines to elucidate the roles of miRNA-31 and miRNA-200a in tumor p

SUBMITTER: Montoya V 

PROVIDER: S-EPMC4574557 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature