The Genomic Basis of Postponed Senescence in Drosophila melanogaster.

ABSTRACT: Natural populations harbor considerable genetic variation for lifespan. While evolutionary theory provides general explanations for the existence of this variation, our knowledge of the genes harboring naturally occurring polymorphisms affecting lifespan is limited. Here, we assessed the genetic divergence between five Drosophila melanogaster lines selected for postponed senescence for over 170 generations (O lines) and five lines from the same base population maintained at a two week generation interval for over 850 generations (B lines). On average, O lines live 70% longer than B lines, are more productive at all ages, and have delayed senescence for other traits than reproduction. We performed population sequencing of pools of individuals from all B and O lines and identified 6,394 gene

SUBMITTER: Carnes MU 

PROVIDER: S-EPMC4574564 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature