Null mutation of the transcription factor inhibitor of DNA binding 3 (id3) affects spermatozoal motility parameters and epididymal gene expression in mice.

ABSTRACT: ID3 is a transcription factor that acts as a dominant-negative regulator of other transcription factors by sequestering them, thus rendering them unable to bind DNA. We have shown previously that ID3 is expressed in a unique, region-specific manner along the epididymis, a highly specialized tissue of the male reproductive tract that functions in the transport and maturation of spermatozoa. The goal of these studies was to test the hypothesis that ID3 plays a role in the epididymis in the region-specific regulation of gene expression that is responsible for establishing the microenvironment required to carry out sperm-related functions. The consequences of ID3 deficiency on epididymal histology and gene expression profiles, as well as spermatozoal motility parameters, were determined. Altho

SUBMITTER: Carroll M 

PROVIDER: S-EPMC4574637 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature