No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity.

ABSTRACT: While most patients affected by the influenza A(H1N1) pandemic experienced mild symptoms, a small fraction required hospitalization, often without concomitant factors that could explain such a severe course. We hypothesize that host genetic factors could contribute to aggravate the disease. To test this hypothesis, we compared the allele frequencies of 547,296 genome-wide single nucleotide polymorphisms (SNPs) between 49 severe and 107 mild confirmed influenza A cases, as well as against a general population sample of 549 individuals. When comparing severe vs. mild influenza A cases, only one SNP was close to the conventional p = 5×10-8. This SNP, rs28454025, sits in an intron of the GSK233 gene, which is involved in a neural development, but seems not to have any connections with immunolo

SUBMITTER: Garcia-Etxebarria K 

PROVIDER: S-EPMC4574704 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature