Global Morbidity and Mortality of Leptospirosis: A Systematic Review.

ABSTRACT:

Background

Leptospirosis, a spirochaetal zoonosis, occurs in diverse epidemiological settings and affects vulnerable populations, such as rural subsistence farmers and urban slum dwellers. Although leptospirosis is a life-threatening disease and recognized as an important cause of pulmonary haemorrhage syndrome, the lack of global estimates for morbidity and mortality has contributed to its neglected disease status.

Methodology/principal findings

We conducted a systematic review of published morbidity and mortality studies and databases to extract information on disease incidence and case fatality ratios. Linear regression and Monte Carlo modelling were used to obtain age and gender-adjusted estimates of disease morbidity for countries and Global Burden of Disease (GBD) and

SUBMITTER: Costa F 

PROVIDER: S-EPMC4574773 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature