Neurocognitive decline in HIV patients is associated with ongoing T-cell activation in the cerebrospinal fluid.

ABSTRACT:

Objective

HIV-associated neurocognitive disorders (HAND) remain a challenge despite combination antiretroviral therapy (cART). Immune cell activation has been implicated to play a major role in the development of HAND.

Methods

In this study, we used multicolor flow cytometry on peripheral blood (PB) and cerebrospinal fluid (CSF) samples to determine the expression of HLA-DR and programmed death-1 (PD-1) on CD4+ and CD8+ T cells in patients with chronic HIV infection. Expression levels were correlated with HI virus load in PB and CSF, classification of HAND and severity of magnetic resonance imaging (MRI) signal abnormalities.

Results

In a cohort of 86 HIV patients we found that the grade of neurocognitive impairment and the severity of MRI signal abnormalities correla

SUBMITTER: Grauer OM 

PROVIDER: S-EPMC4574808 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature