Myopathy in older people receiving statin therapy: a systematic review and meta-analysis.

ABSTRACT:

Objective

The aim of the present study was to determine the risk of myopathy in older people receiving statin therapy.

Methods

Eligible studies were identified searching Ovid Medline, EMBASE, Scopus, CINAHL, Cochrane and PSYCHINFO databases (1987 to July 2014). The selection criteria comprised randomized controlled studies that compared the effects of statin monotherapy and placebo on muscle adverse events in the older adult (65+ years). Data were extracted and assessed for validity by the authors. Odds ratios and 95% confidence intervals (CIs) were used to calculate binary outcomes. Evidence from included studies were pooled in a meta-analysis using Revman 5.3.

Results

The trials assessed in the systematic review showed little or no evidence of a difference in risks

SUBMITTER: Iwere RB 

PROVIDER: S-EPMC4574822 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature