Association between the polymorphisms of urokinase plasminogen activation system and cancer risk: a meta-analysis.

ABSTRACT:

Purpose

The present study aimed to investigate the potential association between the urokinase plasminogen activation (uPA) system polymorphisms (rs4065, rs2227564, and rs344781) and cancer risk.

Methods

An extensive search was performed to identify published case-control studies on the association between the uPA system polymorphisms and cancer risk. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the relationship between the uPA system polymorphisms and cancer risk.

Results

A total of 20 studies comprising 7,037 cancer cases and 10,094 controls were identified and included in the present meta-analysis. Overall, significantly increased cancer risk was associated with the uPA polymorphism rs4065 (T vs C: OR 1.50, 95% CI: 1.19-1.89; TT vs CC

SUBMITTER: Xu Z 

PROVIDER: S-EPMC4574847 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature