Structural Properties of Gene Promoters Highlight More than Two Phenotypes of Diabetes.

ABSTRACT: Genome-wide association studies (GWAS) published in the last decade raised the number of loci associated with type 1 (T1D) and type 2 diabetes (T2D) to more than 50 for each of these diabetes phenotypes. The environmental factors seem to play an important role in the expression of these genes, acting through transcription factors that bind to promoters. Using the available databases we examined the promoters of various genes classically associated with the two main diabetes phenotypes. Our comparative analyses have revealed significant architectural differences between promoters of genes classically associated with T1D and T2D. Nevertheless, five gene promoters (about 16%) belonging to T1D and six gene promoters (over 19%) belonging to T2D have shown some intermediary structural properties

SUBMITTER: Ionescu-Tirgoviste C 

PROVIDER: S-EPMC4574929 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature