Serum Urate and Incident Cardiovascular Disease: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

ABSTRACT:

Objective

There is controversy about whether serum urate (sUA) predicts future cardiovascular disease (CVD) independently of classical risk factors, and the age at which any prediction starts. We studied the sUA-CVD association among generally healthy adults.

Methods

CARDIA recruited 5115 black and white individuals aged 18-30 years in 1985-1986 (year-0). Fatal and nonfatal CVD events by year 27 (n = 164) were ascertained during annual contacts and classified using medical records. The association with sUA (year-0, 10, 15 and 20) was modeled using Cox proportional hazards regression, pooling over gender-specific quartiles.

Results

Mean sUA concentration was higher in men than women, but increased over time in both genders. Those with elevated sUA had worse metabolic p

SUBMITTER: Wang H 

PROVIDER: S-EPMC4575092 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature