The Prognostic Importance of Changes in Renal Function during Treatment for Acute Heart Failure Depends on Admission Renal Function.

ABSTRACT:

Background

Worsening and improving renal function during acute heart failure have been associated with adverse outcomes but few studies have considered the admission level of renal function upon which these changes are superimposed.

Objectives

The objective of this study was to evaluate definitions that incorporate both admission renal function and change in renal function.

Methods

696 patients with acute heart failure with calculable eGFR were classified by admission renal function (Reduced [R, eGFR<45 ml/min] or Preserved [P, eGFR≥45 ml/min]) and change over hospital admission (worsening [WRF]: eGFR ≥20% decline; stable [SRF]; and improving [IRF]: eGFR ≥20% increase). The primary outcome was all-cause mortality. The prevalence of Pres and Red renal function was 47.8

SUBMITTER: Reid R 

PROVIDER: S-EPMC4575105 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature