Tailoring Adjuvant Radiation Therapy by Intraoperative Imaging to Detect Residual Cancer.

ABSTRACT: For many solid cancers, radiation therapy is offered as an adjuvant to surgical resection to lower rates of local recurrence and improve survival. However, a subset of patients treated with surgery alone will not have a local recurrence. Currently, there is no way to accurately determine which patients have microscopic residual disease in the tumor bed after surgery and therefore are most likely to benefit from adjuvant radiation therapy. To address this problem, a number of technologies have been developed to try to improve margin assessment of resected tissue and to detect residual cancer in the tumor bed. Moreover, some of these approaches have been translated from the preclinical arena into clinical trials. Here, we review different types of intraoperative molecular imaging systems for

SUBMITTER: Whitley MJ 

PROVIDER: S-EPMC4575408 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature