A Novel Collagen Matricryptin Reduces Left Ventricular Dilation Post-Myocardial Infarction by Promoting Scar Formation and Angiogenesis.

ABSTRACT:

Background

Proteolytically released extracellular matrix (ECM) fragments, matricryptins, are biologically active and play important roles in wound healing. Following myocardial infarction (MI), collagen I, a major component of cardiac ECM, is cleaved by matrix metalloproteinases (MMPs).

Objectives

This study identified novel collagen-derived matricryptins generated post-MI that mediate remodeling of the left ventricle (LV).

Methods

Recombinant collagen Ia1 was used in MMPs cleavage assays, the products were analyzed by mass spectrometry for identification of cleavage sites. C57BL6/J mice were given MI and animals were treated either with vehicle control or p1158/59 matricryptin. Seven days post-MI, LV function and parameters of LV remodeling were measured. Levels of p

SUBMITTER: Lindsey ML 

PROVIDER: S-EPMC4575409 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature