Ascaris lumbricoides β carbonic anhydrase: a potential target enzyme for treatment of ascariasis.

ABSTRACT:

Background

A parasitic roundworm, Ascaris lumbricoides, is the causative agent of ascariasis, with approximately 760 million cases around the world. Helminthic infections occur with a high prevalence mostly in tropical and developing xcountries. Therefore, design of affordable broad-spectrum anti-helminthic agents against a variety of pathogens, including not only A. lumbricoides but also hookworms and whipworms, is desirable. Beta carbonic anhydrases (β-CAs) are considered promising targets of novel anthelminthics because these enzymes are present in various parasites, while completely absent in vertebrates.

Methods

In this study, we identified an A. lumbricoides β-CA (AIBCA) protein from protein sequence data using bioinformatics tools. We used computational biology resour

SUBMITTER: Zolfaghari Emameh R 

PROVIDER: S-EPMC4575479 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature