New insights into the mechanisms of Treg function.

ABSTRACT:

Purpose of review

CD4Foxp3 regulatory T cells (Tregs) are crucial in controlling immunity and self-tolerance. Consequently, in transplantation, Tregs play a central role in inhibiting acute rejection and promoting allograft tolerance. A more complete understanding of Treg biology may lead to novel therapeutic approaches to enhance Treg numbers and function.

Recent findings

The maintenance of self-tolerance in nonlymphoid tissues requires the differentiation of Tregs in secondary lymphoid organs from naïve-like central Tregs into effector Tregs. Antigen and environmental cues guide this Treg differentiation, which parallels the types of adaptive immune responses taking place, allowing them to enter and function within specific nonlymphoid tissues. In addition to controlling i

SUBMITTER: Rothstein DM 

PROVIDER: S-EPMC4575588 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature