Opioids and breast cancer recurrence: A Danish population-based cohort study.

ABSTRACT:

Background

Opioids may alter immune function, thereby potentially affecting cancer recurrence. The authors investigated the association between postdiagnosis opioid use and breast cancer recurrence.

Methods

Patients with incident, early stage breast cancer who were diagnosed during 1996 through 2008 in Denmark were identified from the Danish Breast Cancer Cooperative Group Registry. Opioid prescriptions were ascertained from the Danish National Prescription Registry. Follow-up began on the date of primary surgery for breast cancer and continued until breast cancer recurrence, death, emigration, 10 years, or July 31, 2013, whichever occurred first. Cox regression models were used to compute hazard ratios and 95% confidence intervals associating breast cancer recurrence with o

SUBMITTER: Cronin-Fenton DP 

PROVIDER: S-EPMC4575607 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature