Frequency of discrepancies in retracted clinical trial reports versus unretracted reports: blinded case-control study.

ABSTRACT:

Objectives

To compare the frequency of discrepancies in retracted reports of clinical trials with those in adjacent unretracted reports in the same journal.

Design

Blinded case-control study.

Setting

Journals in PubMed.

Population

50 manuscripts, classified on PubMed as retracted clinical trials, paired with 50 adjacent unretracted manuscripts from the same journals. Reports were randomly selected from PubMed in December 2012, with no restriction on publication date. Controls were the preceding unretracted clinical trial published in the same journal. All traces of retraction were removed. Three scientists, blinded to the retraction status of individual reports, reviewed all 100 trial reports for discrepancies. Discrepancies were pooled and cross checked before

SUBMITTER: Cole GD 

PROVIDER: S-EPMC4575810 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature